Although Wellbutrin and Adderall work differently and belong to different classes of drugs, both medications can be effective for reducing symptoms of ADHD, like inattention and impulsivity. I do find that Wellbutrin helps with mood swings and helps temper the irritability that comes when my ADHD meds wear off. The crash isn’t severe as long as I’m eating small meals throughout the day. Wellbutrin is an antidepressant sometimes prescribed off-label for ADHD. It may be used to help manage symptoms like hyperactivity and attention deficits when traditional stimulants prove effective. While stimulant medications are the first line of treatment, research has shown that using Wellbutrin may help to improve ADHD symptoms, including impulsivity, hyperactivity, and inattention. If your doctor suggested bupropion (brand name: Wellbutrin) for ADHD, you may have questions. This guide presents evidence-based information on how it works, what research shows about its effectiveness, realistic timelines, side effects, and practical considerations such as insurance. Wellbutrin (bupropion) is sometimes prescribed off-label for ADHD. Learn how it works, who it helps most, side effects, and how it compares to traditional stimulant medications. In the United States, the treatment of attention deficit hyperactivity disorder (ADHD) is not an approved indication of bupropion, and it is not mentioned in the 2019 guideline on ADHD treatment from the American Academy of Pediatrics. [63] The FDA hasn’t approved Wellbutrin to treat attention deficit hyperactivity disorder (ADHD). Still, some doctors may prescribe Wellbutrin off-label to treat ADHD. Wellbutrin is an antidepressant sometimes used off-label to treat ADHD in adults. Wellbutrin can be taken alone or with a stimulant like Adderall to help manage ADHD symptoms. Wellbutrin (bupropion) can be prescribed off-label to treat ADHD. It can help with ADHD by influencing certain chemicals in the brain, namely norepinephrine and dopamine, which play a role in attention and impulsive control.